Thanks to your donations in 2020, we were able to start the nanoparticle trials needed to demonstrate safety. so that clinical trial can start!
 COVID-19 has been tough, but we are tougher!!

Join Our Fundraising-

 Seize the Ribbon Foundation for Bladder Cancer Research was founded in 2010 by the Miningham Family.
The foundation supports the work of
Drs. John Phillips and Senuki Konno at New York Medical College supporting innovative and progressive treatment of Bladder Cancer with research work in both molecular and herbal approaches to bladder cancer treatments.
 
 

THANK YOU !
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Our 2019 Newsletter!
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Seize The Ribbon has two doctors working to find bladder cancer destroying answers at New York Medical College in Valhalla, NY.

New York Medical College is the leading academic biomedical research center between New York City and the New York state capital of Albany. The College manages research and other sponsored programs, notably in the areas of cancer, cardiovascular disease, infectious diseases, kidney disease, the neurosciences, disaster medicine, and vaccine development.

                                                      

Abstract Oxidative stress (OXS) has been recently considered as one of anticancer strategies by taking advantage of higher vulnerability of cancer cells (than normal cells) to OXS. In fact, the successful outcomes using OXS have been reported in several cancer cases. A medicinal mushroom extract, PE isolated from Poria mushroom, has been shown to have anticancer/antitumor activity
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Purpose: Although several therapeutic options for bladder cancer are available, the poor efficacy and palpable side effects are a major concern. Establishing a more effective intervention is urgently demanded. Glycolysis is considered a strategic target and has been often investigated in various cancers
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  Robert Miningham
  04/1942-4/2010
 Seize the Ribbon Foundation for
Bladder Cancer Research was started in his honor
and with his help in 2010.

Seize the Ribbon is a Bladder Cancer Research charitable organization that started with a symbol that was created by an artist for her dad to raise money .The ribbon was for the fight against bladder cancer and the hand was for his strength. Together symbolizing hope.

  He died on 4/15/10 but before this time he helped Seize the Ribbon form a plan for a foundation that would help fight Bladder Cancer.
When Seize the Ribbon became active in fundraising and decided to fund Bladder Cancer Research they found Dr. Phillips (who had been part of Robert’s Urology  team) and Dr. Konno working on bladder cancer research in NY Medical College. Their work was/ is the innovative and progressive treatment of Bladder Cancer with research work in both molecular and herbal approaches to bladder cancer treatments.
A mission was formed not long after Robert’s death that involved family and friends working without compensation to raise money each year to continue to support the doctors in their ground breaking research.
Now we are proud to say in 2018 that we are growing as a 501c3 Charitable Organization that has since 2010 raised  $139,900.and Every penny raised still supports Bladder Cancer Research at NYMC in Vallaha NY.

We are proud of how far we have come in such a short time! Since 2010 we have continued to grow.

-We are a 501(c)3 foundation

-We are a registered New York Charity

- New York Medical School has set up an account for ‘Seize the Ribbon’. This allows us the ability to directly fund Bladder Cancer Research.

-We have created  Annual fundraisers- 
Walk-a-thons  and the Harvest party in October. both are used for education as well.

-Seize the Ribbon also sponsors local school fundraisers.

-Our new goal for 2019 is to donate $35,000 to Bladder Cancer Research.

Other sources of fundraising we have-

-We have t-Shirts, hats and jewelry with our symbol for anyone who is fighting cancer and the ability to color the ribbon for your fight.  

-Seize the Ribbon is also available on Facebook! We share our stories and news.

Most important is that our foundation is run by family and friends with donated time.

 

Seen here is the research team of Dr. Konno (Left), Dr. Valera (middle) Dr. Philipps (right

Dr. John Phillips 
Bladder Cancer Research
 MD, FACS
Bladder cancer research of Nano-particle technology to improve effectiveness
of intravesical chemotherapy delivery
                             

 Dr.Sensuke Konno, Ph.D
Bladder cancer research of Pharmacology of
Mitake/Poria Mushroom combined with Vitamin C

​  We would first like to thank all of our supporters from last year and tell you that because of your donations to Seize the Ribbon, we have been able to support innovation and progress in the treatment of bladder cancer, a disease known for its great toll on quality of life, life expectancy, and cost of therapy. Your efforts have supported Drs. John Phillips and Senuki Konno at New York Medical College who continue the groups’ work in both molecular and herbal approaches to bladder cancer treatments. 
 FOLLOW OUR PROGRESS-
Updates- Despite Covid-19 shut downs funds were still raised and research continued. Two new research fellows were added to the team. Welcome Drs. Maheen Hossain and Danielle Guilfoil! And Dr. Phillips started nanoparticle trials to prove safety! Also publications written about Chemosensitizing effect of maitake mushroom extracton carmustine cytotoxicity in human bladder cancer cells was written by Dr. Konno 
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Update from  DR. Phillips: August 2019- "Our laboratory continues to make progress with nanoparticle therapies for bladder cancer thanks to Seize the Ribbon support.  Nanoparticles are mere, microscopic packages of proteins or fat globules that 'hold in' other compounds like chemotherapies.  Nanoparticles are very temperamental and require sophisticated preparations and 'quality testing' to ensure that they are of the correct size, shape, integrity, and stability, and carry the correct dose of chemotherapy, before there use in any cancer trial.  Part of the STR funds are going towards demonstrating the correct dosing and effect of nanoparticle chemotherapy combination on bladder cancers as well as the quality steps required for safe administration in a clinical trial setting."

We have had challenges in timing the preparation of the nanoparticles with the age and disease burden of the experimental transgenic mouse population, which are rather fragile because of their cancers.  We're still making progress!

​Updated research news from Dr. Phillips 10/2018-
​"Seize the Ribbon funds went directly to inaugurate new research in bladder cancer nano-therapy.  Using a transgenic mouse model, New York Medical College researchers, in collaboration with Bio-Pharma, used a custom-designed nanoparticle that carries a chemotherapy weapon as a 'Trojan Horse'.  The mice otherwise develop bladder cancer and pass away earlier than their normal littermates.  With nano-particle Trojan Horse, in early results, appears to eradicate bladder cancer leaving only non-cancerous but inflammed cells behind.  The group now hopes to expand the research to test different doses of the nano-particles and different chemotherapies packaged within them.  Ultimately, Seize the Ribbon fund will support the development of new nano-treatments for bladder cancer in human trials by completing these critical pre-clinical laboratory efforts."

Updated research news from Dr. Phillips: 3/2018-A recent advance was achieved by the group's post-doctoral resident, Dr. Vladimir Valera, who presented his findings on Seize the Ribbon-supported research at last year’s Society of Urologic Oncology in Washington DC. Dr. Valera’s work was awarded first prize beating out researches from Harvard, Memorial Sloane Kettering, and John Hopkins. The research team is also working on a combination approach of Vitamin C and Mitake mushroom exacts which are shown to be safe for human consumption. A clinical trial for early bladder cancers is underway and interested participants can contact Dr. Konno or Dr. Phillips at 914 594 2440 .We want to emphasize that while we focus on Bladder Cancer, Seize the Ribbon supported research dollars from you go beyond a specific cancer and may aid in finding answers to help fight other cancers as well.
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News from 11/29/17
Thanks to crucial support from Seize the Ribbon, much has happened with the progress in our research program against bladder cancer. We have a unique genetic mouse model of bladder cancer that we have studied showing the relationship between the expression of a defective gene, Uroplakin, and the development of early bladder cancers. We also have been able to determine the expression level of the Uroplakin gene to identify mouse candidates for our new nanoparticle drug trial. One drug, under development by a partner research firm, Phosphorex, will be used to attack the bladder cancers in genetically affected mice. A second drug, under partnership with Johns Hopkins, will be used to attack bladder cancers that do not specifically express mutant Uroplakin gene. By our next report, we should have rather innovative data as a basis for translational trials. With gratitude and great appreciation John

News From 4/9/16-
Dr. Phillips talked about exciting new developments during the walkathon-

The bladder has an inner lining well suited as a reservoir. The bladder expands at low pressure, empties while protecting the kidneys from short increases in pressure, and the bladder is nearly impermeable so foreign substances are not absorbed. The impermeability decreases the effectiveness of chemotherapy placed directly into the bladder. Most bladder cancers could be treated if chemotherapy were more effective. We established a collaboration with researchers from NYU and from Qualiber, a tech start up from Chapel Hill, in which chemotherapy is delivered into the bladder packed within tiny nanoparticles. The nanoparticles attach to the bladder wall and are absorbed easily. Then, the packaging or envelope layer of the nanoparticle dissolves releasing the chemotherapy. Our plan, using Seize the Ribbon support, is to test nanoparticle effectiveness in treating bladder cancers in an engineered mouse that develops bladder cancers early in life. Such work is critical to demonstrating effectiveness and safety before moving ahead with any clinical trial

    News from 2015-

1. Dr. Konno published his work on bladder cancer and the anti-cancer effect of herbal drugs in an important journal, citing "Seize the Ribbon" support in the acknowledgements.

2. Dr. Valera submitted his research on a new drug in bladder cancer at last weeks' Society of Urologic Oncology meeting in Washington.  There were 200 abstracts submitted and Vladimir's work was chosen as 1st prize for his session.   Besides Vladimir, the other 6 awardees were from the Mayo Clinic, Memorial Sloane Kettering, Cornell, Johns Hopkins, and the University of Georgia.  "Pretty good company". 

From 2014-

Dr.Philips was explaining while walking together during Seize the Ribbon walk-a-thon ...Here is a short synopsis of the current in-vivo work: 

Extracts of maitake mushrooms called the maitake D-fraction (PDF) appear to synergize with vitamin C (VC) in producing an anti-tumor effect. We are currently determining whether there is a tissue- and dose-specific effect of the PDF/VC combination in a controlled murine model. A Phase III trial is being established to determine whether PDF/VC decreases the recurrence and/or progression rate of superficial bladder cancers. The target of PDF/VC appears to be cell cycle regulatory proteins, p21 and p53. We aim to determine whether tumor expression of these two molecules, or the expression of Fibroblast Growth Factor Receptor-III (FGFR-III) predicts responsiveness to PDF/VC. 

Extracts of maitake mushrooms called the maitake D-fraction (PDF) appear to synergize with vitamin C (VC) in producing an anti-tumor effect. We are currently determining whether there is a tissue- and dose-specific effect of the PDF/VC combination in a controlled murine model. A Phase III trial is being established to determine whether PDF/VC decreases the recurrence and/or progression rate of superficial bladder cancers. The target of PDF/VC appears to be cell cycle regulatory proteins, p21 and p53. We aim to determine whether tumor expression of these two molecules, or the expression of Fibroblast Growth Factor Receptor-III (FGFR-III) predicts responsiveness to PDF/VC.

HELPFUL SITES AND INFORMATION-

We are working on getting more information from users of Bladder products.Please send us an email or post on Seize the ribbon facebook page to recommend products 


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Did you know: Over 81,000 will be diagnosed with bladder cancer in a year

Signs-Blood in the urine, Painful urination, Urgent need to urinate, Feeling the need but not able to urinate
Symptoms-Abdominal pain, Fatigue, Lower back pain, Appetite or weight loss
 
Risk Factors-Smoking, Race, gender and age, Medical history of cancer, Chronic bladder inflammation


 

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