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| Seize The Ribbon Newsletter |
Robert Miningham
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Dr. John Philipps,
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Seize the Ribbon is a Bladder Cancer Research charitable organization that started with a symbol that was created by an artist for her dad .The ribbon was for the fight against bladder cancer and the hand was for his strength. Together symbolizing hope.
He died on 4/15/10 but before this time he helped Seize the Ribbon form a plan for a foundation that would help fight Bladder Cancer. Dr. John Philipps, MD, FACS was part of a team of doctors that worked on Robert Miningham’s case. When Seize the Ribbon became active in fundraising and decided on funding Bladder Cancer Research they found that Dr. Phillips was top in his field of research and was working out of NY Medical College. We are proud of how far we have come in such a short time! Since 2010 we have continued to grow. -We are a 501(c)3 foundation -We are a registered New York Charity - M&O Systems, the company Robert founded is our corporate sponsor - New York Medical School has set up an account for ‘Seize the Ribbon’. This allows us the ability to directly fund Dr. John Phillip's Bladder Cancer Research. -We have created Annual fundraisers- Walk-a-thons and the Harvest Costume party in October. both are used for education as well. -Seize the Ribbon also sponsors local school fundraisers. -In December of 2010 we donated $5,000, in December of 2011 we have reached our $10,000 goal. In 2012 we donated $14,500, and in 2013 we donated $20,000. In 2014 we raised and donated $20,000.$25,400 in 2015 -Our new goal for 2016 is to donate $30,000 to Dr. John Philipps and his team for Bladder Cancer Research. Other sources of fundraising we have- -We have t-Shirts, hats and jewelry with our symbol for anyone who is fighting cancer and the ability to color the ribbon for your fight. -Seize the Ribbon is also available on Facebook! We share our stories and news. Most important is that our foundation is run by family and friends with donated time. |
Seize the Ribbon donates $25,400 to Bladder Cancer Research. From left-Terry Haas,Barbara Miningham,Dr.Kono,Elisabeth Miningham,Sean Haggerty the Ceo of M&O Systems,Dr.Phillips and Dr.Esghi
Seen here is the research team of Dr. Konno (Left), Dr. Valera (middle) Dr. Philipps (right
The CEO of M&O Systems durring a guided tour of the research lab looking at slides of Bladder Cancer
Extracts of maitake mushrooms called the maitake D-fraction (PDF) appear to synergize with vitamin C (VC) in producing an anti-tumor effect. We are currently determining whether there is a tissue- and dose-specific effect of the PDF/VC combination in a controlled murine model. A Phase III trial is being established to determine whether PDF/VC decreases the recurrence and/or progression rate of superficial bladder cancers. The target of PDF/VC appears to be cell cycle regulatory proteins, p21 and p53. We aim to determine whether tumor expression of these two molecules, or the expression of Fibroblast Growth Factor Receptor-III (FGFR-III) predicts responsiveness to PDF/VC.
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We would first like to thank all of our supporters from last year and tell you that because of your donations to Seize the Ribbon, we have been able to support innovation and progress in the treatment of bladder cancer, a disease known for its great toll on quality of life, life expectancy, and cost of therapy. Your efforts have supported Drs. John Phillips and Senuki Konno at New York Medical College who continue the groups’ work in both molecular and herbal approaches to bladder cancer treatments. A recent advance was achieved by the group's post-doctoral resident, Dr. Vladimir Valera, who presented his findings on Seize the Ribbon-supported research at last year’s Society of Urologic Oncology in Washington DC. Dr. Valera’s work was awarded first prize beating out researches from Harvard, Memorial Sloane Kettering, and John Hopkins. The research team is also working on a combination approach of Vitamin C and Mitake mushroom exacts which are shown to be safe for human consumption. A clinical trial for early bladder cancers is underway and interested participants can contact Dr. Konno or Dr. Phillips at 914 594 2440 .We want to emphasize that while we focus on Bladder Cancer, Seize the Ribbon supported research dollars from you go beyond a specific cancer and may aid in finding answers to help fight other cancers as well.
News From 4/9/16- Dr. Phillips talked about exciting new developments during the walkathon- The bladder has an inner lining well suited as a reservoir. The bladder expands at low pressure, empties while protecting the kidneys from short increases in pressure, and the bladder is nearly impermeable so foreign substances are not absorbed. The impermeability decreases the effectiveness of chemotherapy placed directly into the bladder. Most bladder cancers could be treated if chemotherapy were more effective. We established a collaboration with researchers from NYU and from Qualiber, a tech start up from Chapel Hill, in which chemotherapy is delivered into the bladder packed within tiny nanoparticles. The nanoparticles attach to the bladder wall and are absorbed easily. Then, the packaging or envelope layer of the nanoparticle dissolves releasing the chemotherapy. Our plan, using Seize the Ribbon support, is to test nanoparticle effectiveness in treating bladder cancers in an engineered mouse that develops bladder cancers early in life. Such work is critical to demonstrating effectiveness and safety before moving ahead with any clinical trial News from 2015- 1. Dr. Konno published his work on bladder cancer and the anti-cancer effect of herbal drugs in an important journal, citing "Seize the Ribbon" support in the acknowledgements. 2. Dr. Valera submitted his research on a new drug in bladder cancer at last weeks' Society of Urologic Oncology meeting in Washington. There were 200 abstracts submitted and Vladimir's work was chosen as 1st prize for his session. Besides Vladimir, the other 6 awardees were from the Mayo Clinic, Memorial Sloane Kettering, Cornell, Johns Hopkins, and the University of Georgia. "Pretty good company". From 2014- Dr.Philips was explaining while walking together during Seize the Ribbon walk-a-thon ...Here is a short synopsis of the current in-vivo work: Extracts of maitake mushrooms called the maitake D-fraction (PDF) appear to synergize with vitamin C (VC) in producing an anti-tumor effect. We are currently determining whether there is a tissue- and dose-specific effect of the PDF/VC combination in a controlled murine model. A Phase III trial is being established to determine whether PDF/VC decreases the recurrence and/or progression rate of superficial bladder cancers. The target of PDF/VC appears to be cell cycle regulatory proteins, p21 and p53. We aim to determine whether tumor expression of these two molecules, or the expression of Fibroblast Growth Factor Receptor-III (FGFR-III) predicts responsiveness to PDF/VC. |
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